Color-changing gel could enhance cataract surgery safety, efficiency

Editor's Note

Johns Hopkins researchers have developed a fluorescent hydrogel that may improve outcomes in cataract surgery by aiding in the complete removal of residual gel, reducing complications such as increased eye pressure, pain, and potential vision loss, Medical Xpress reported October 31.

Cataract surgery, a frequently performed procedure, involves removing the eye’s cloudy lens and inserting an artificial one. A clear hydrogel, used to maintain eye structure and protect the cornea during surgery, must be entirely removed afterward to prevent complications. Developed by Erick Rocher and Dr. Allen Eghrari, the novel hydrogel remains clear during surgery and fluoresces green under blue light, helping surgeons ensure no residual gel remains, Medical Xpress reports.

According to the article, traditional dyeing methods present challenges due to risk of the dye leaking and obscuring visibility. The new approach uses chemically bonded fluorescein and hyaluronic acid, ensuring that only the gel glows to facilitate complete removal. Digital microscopes can further enhance gel visibility without needing blue light.

Results published in the Journal of Cataract & Refractive Surgery emphasize the gel’s potential to streamline surgery and reduce postoperative complications. Each component of the gel is already clinically approved, with the new chemical bonding process maintaining appropriate viscosity and usability, making it compatible with existing surgical techniques.

According to the article, Rocher and Eghrari also filed a provisional patent application on the work. While promising in animal models, human trials are needed to confirm the gel's effectiveness and safety, they say. The research team aims to address scaling production and optimizing dye concentration to bring this technology to clinical practice.