Editor's Note A study analyzing data from 124,577 suspected sepsis cases across 236 US hospitals found that antibiotic de-escalation—switching to narrower-spectrum antibiotics or stopping broad-spectrum antibiotics—occurred in less than 30% of cases but was associated with improved patient outcomes, according to December 6 report from the Center for Infectious Disease…

Read More

Editor's Note Non-operative management (NOM) with antibiotics for pediatric uncomplicated appendicitis is both less expensive and slightly more effective than urgent laparoscopic appendectomy over a one-year period, according to a study published November 19 in the Journal of the American College of Surgeons. The findings support the viability of NOM…

Read More

Editor's Note Research shows antibiotic-resistant infections could lead to 8.2 million deaths annually by 2050, representing a 75% increase from current rates, according to a September 17 article in HealthDay. Published in the Lancet, the new study highlights the growing threat of growing threat of antimicrobial resistance (AMR), predicting that…

Read More

Editor's Note A 13-year study at US Veterans Affairs (VA) medical centers found a decline in both hospital-associated infections (HAIs) and antimicrobial resistance for common pathogens, MedPage Today August 15 reports. From 2007 to 2019, the overall infection rate of nine pathogens decreased, with an average annual percentage change (AAPC)…

Read More

Editor's Note Evidence is mounting for the use of antibiotics as a valid alternative to surgery for acute appendicitis, including in pediatric cases, the Washington Post reported August 17. The article details how this treatment—described as a “dark secret” by one expert testifying to its use in the 1950s, prior…

Read More

Editor's Note Most healthcare-associated surgical site infections are not caused by pathogens acquired in the hospital, but by previously harmless bacteria already present on patients’ skin prior to being admitted, according to a study published April 10 in Science Translational Medicine. Surgical site infections account for the highest annual costs…

Read More

Editor's Note The US Food and Drug administration approved Zevtera for treating Staphylococcus aureus bacteremia (SAB) bloodstream infections, which are often acquired in healthcare settings. In the April 3 announcement, the agency notes the new antibiotic Zevtera (ceftobiprole medocaril sodium for injection) is effective for SAB-infected patients with right-sided infective…

Read More

Editor's Note Findings published March 4 in Jama Network show that preoperative urine culture is a low-value intervention for most surgical patients and should be de-implemented. Despite guidelines to the contrary from Infectious Diseases Society of America and the American College of Physicians, preoperative urine testing and antibiotic treatment persists…

Read More

Editor's Note: A point-of-care, antimicrobial coating for orthopedic implants could soon make implant-associated infections a problem of the past, UCLA Health reported on January 3. Developed by two UCLA surgeons, the coating is designed to kill or slow the spread of micro-organisms in order to prevent post-surgical infections. According to…

Read More

Editor's Note Widespread antibiotic resistance globally has meant that drugs used to treat common infections in children and babies are no longer effective, according to a new study published on October 31 by Science Direct. The study found that a number of antibiotics recommended by the World Health Organization (WHO)…

Read More