Editor's Note A systematic review found no strong evidence that compliance with the CMS Severe Sepsis and Septic Shock Management Bundle (SEP-1) reduces mortality, raising questions about its inclusion in hospital performance measures, according to a February 19 report from the University of Minnesota’s Center for Infectious Disease Research and…
Editor's Note A cohort study published February 24 in JAMA Pediatrics found that prophylactic antibiotics reduced the odds of surgical site infections (SSIs) by 72% in children undergoing cholecystectomy for uncomplicated cholelithiasis. However, extended-spectrum antibiotics offered no additional benefit over cefazolin, suggesting that simpler prophylaxis protocols could optimize outcomes while…
Editor's Note The first large-scale, randomized pediatric trial of its kind reveals the potential of treating acute, non-perforated appendicitis in children with antibiotics instead of surgery, Medical Xpress reported January 20. Published in The Lancet, the APPY study involved collaboration among 11 children’s hospitals worldwide to compare the effectiveness of…
Editor's Note A study analyzing data from 124,577 suspected sepsis cases across 236 US hospitals found that antibiotic de-escalation—switching to narrower-spectrum antibiotics or stopping broad-spectrum antibiotics—occurred in less than 30% of cases but was associated with improved patient outcomes, according to December 6 report from the Center for Infectious Disease…
Editor's Note Non-operative management (NOM) with antibiotics for pediatric uncomplicated appendicitis is both less expensive and slightly more effective than urgent laparoscopic appendectomy over a one-year period, according to a study published November 19 in the Journal of the American College of Surgeons. The findings support the viability of NOM…
Editor's Note Research shows antibiotic-resistant infections could lead to 8.2 million deaths annually by 2050, representing a 75% increase from current rates, according to a September 17 article in HealthDay. Published in the Lancet, the new study highlights the growing threat of growing threat of antimicrobial resistance (AMR), predicting that…
Editor's Note A 13-year study at US Veterans Affairs (VA) medical centers found a decline in both hospital-associated infections (HAIs) and antimicrobial resistance for common pathogens, MedPage Today August 15 reports. From 2007 to 2019, the overall infection rate of nine pathogens decreased, with an average annual percentage change (AAPC)…
Editor's Note Evidence is mounting for the use of antibiotics as a valid alternative to surgery for acute appendicitis, including in pediatric cases, the Washington Post reported August 17. The article details how this treatment—described as a “dark secret” by one expert testifying to its use in the 1950s, prior…
Editor's Note Most healthcare-associated surgical site infections are not caused by pathogens acquired in the hospital, but by previously harmless bacteria already present on patients’ skin prior to being admitted, according to a study published April 10 in Science Translational Medicine. Surgical site infections account for the highest annual costs…
Editor's Note The US Food and Drug administration approved Zevtera for treating Staphylococcus aureus bacteremia (SAB) bloodstream infections, which are often acquired in healthcare settings. In the April 3 announcement, the agency notes the new antibiotic Zevtera (ceftobiprole medocaril sodium for injection) is effective for SAB-infected patients with right-sided infective…
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