Editor's Note A team of University of California, Los Angeles (UCLA) biologists have found that combinations of three different antibiotics can overcome a bacteria’s resistance, even when none of the three on its own or two together is effective, the February 7 UCLA Newsroom reports. The biologists created a mathematical…

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Editor's Note This study from the UK is the first to link antibiotic resistance with exposure to the disinfectant chlorhexidine. In five of six strains of Klebsiella pneumoniae exposed to chlorhexidine-containing disinfectants in the laboratory, adaptation to chlorhexidine led to resistance to the last resort antibiotic colistin. The risk of…

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Editor's Note Single-dose antibiotic prophylaxis was associated with fewer peripheral and epidural catheter infections, this study finds. The study included 11,307 regional anesthesia patients with single-dose antibiotic prophylaxis and 11,307 controls who did not receive antibiotics. For peripheral catheters, the incidence of infections without antibiotics was 2.4%, compared with 1.1%…

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Editor's Note Officials from the Centers for Disease Control and Prevention on May 27 reported the first US case of Escherichia coli (E coli) bacteria that is resistant to colistin, a last-resort antibiotic, Reuters reports. A 49-year old woman in Pennsylvania was found last month to have a urinary tract…

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Editor's Note Though US hospitals are making gains in the fight against healthcare-associated infections (HAIs) and antibiotic-resistant bacteria, too many patients continue to get these infections, according to a Vital Signs report released March 3 by the Centers for Disease Control and Prevention (CDC). Among the findings in the report:…

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Editor's Note Patients at Veterans Affairs hospitals who developed postoperative Clostridium difficile infections had a five times higher risk of mortality and a twelve times higher risk of morbidity in this study. This analysis of nearly 500,000 surgical procedures found that out of more than 1,800 patients who developed C…

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Editor's Note Some 120,000 more patients would get surgical site infections (SSIs) and 6,300 more would die from those infections if antibiotics given before surgery become 30% less effective, this study finds. Researchers estimated that between 38.7% and 50.9% of pathogens causing SSIs in the US are resistant to standard…

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The Food and Drug Administration in May 2011 approved the first new drug in 25 years to treat diarrhea caused by Clostridium difficile, a pathogen that one study suggests may have surpassed methicillin-resistant Staphylococcus aureus as the leading hospital-acquired infection, according to the New York Times. In clinical trials, fidaxomicin…

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Hardwiring the process for giving and discontinuing prophylactic antibiotics for surgery helped a university hospital drive up compliance with national guidelines, the July 2008 Journal of the American College of Surgeons reports. Finding education wasn't enough, the authors developed a process with "hard stops" at key points before and after…

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