Study: Preoperative stereotactic radiosurgery shows promise in brain metastases management
Editor's Note A new international study reports low rates of local recurrence, radionecrosis, and leptomeningeal disease in patients receiving neoadjuvant stereotactic radiosurgery (SRS) before brain metastases resection, Medscape Medical News reported January 6. Published in Radiotherapy and Oncology, the analysis included 179 patients with 189 brain metastases treated at nine…
First ACS cancer report highlights neoadjuvant therapy expansion, improvements
Editor's Note A significant increase in the use of neoadjuvant systemic cancer therapies is among the most notable findings from the first annual cancer report from The American College of Surgeons (ACS) National Cancer Database (NCDB). The report also emphasizes the value of early detection, innovative therapies, and robust datasets…
Study: Surgeries improve survival in young BRCA-positive breast cancer patients
Editor's Note Preliminary research shows removing breasts or ovaries can significantly improve survival and reduce recurrence risk in young breast cancer patients with BRCA mutations, HealthDay reported December 13. The findings were presented this week at the San Antonio Breast Cancer Symposium. According to the article, researchers analyzed data from…
Study: Active monitoring without surgery safe for certain low-risk DCIS patients
Editor's Note Active monitoring for certain breast cancer patients offers similar outcomes to surgery with fewer side effects, according to research detailed in a December 16 article from Oncology News Central. Presented at the 2024 San Antonio Breast Cancer Symposium and published in JAMA, The COMET trial supports the safety…
Data support option to skip sentinel lymph node biopsy in early breast cancer
Editor's Note Skipping sentinel lymph node biopsy (SLNB) in patients with clinically node-negative early breast cancer provides noninferior outcomes compared to undergoing the procedure, MedPage Today reported December 13. Presented at the San Antonio Breast Cancer Symposium and published in the New England Journal of Medicine, the INSEMA trial found…
Q&A: Perioperative immunotherapy advances for early-stage NSCLC
Editor's Note Perioperative immunotherapy is reshaping treatment strategies for early-stage non-small cell lung cancer (NSCLC) without actionable mutations, according to Dr. Roy S. Herbst of Yale Cancer Center. In a recent interview with OncLive, the oncology expert highlighted the promise of neoadjuvant and adjuvant therapies to improve outcomes for these…
Algorithm enhances decision-making on intermediate-stage liver cancer surgery, treatment
Editor's Note An algorithm developed by researchers at Duke University Medical Centre is designed to assist patients diagnosed with intermediate-stage liver cancer in making decisions about surgery, according to an October 9 report in News Medical Life Sciences. Known as the Modified Metroticket, this tool predicts overall survival and recurrence-free…
Immunotherapy’s FDA approval expected to improve lung cancer treatment
Editor's Note The US Food & Drug Administration (FDA) has approved immunotherapy durvalumab for perioperative treatment of resectable non-small cell lung cancer (NSCLC), according to an August 15 announcement. The approval is for durvalumab (Imfinzi, AstraZeneca) in combination with platinum-based chemotherapy as a neoadjuvant treatment, followed by durvalumab alone as…
Study: Starting adjuvant chemotherapy more than 6 weeks after surgery worsens colorectal cancer survival
Editor's Note A post hoc analysis of the SCOT phase 3 randomized clinical trial reveals that initiating adjuvant chemotherapy more than 6 weeks after surgery is linked to worse disease-free survival (DFS) in patients with high-risk stage II and stage III colorectal cancer. Published June 12 in JAMA Surgery, the…
Study reveals puzzling paradox on bilateral mastectomy, breast cancer survival outcomes
Editor's Note Medical professionals have long accepted that bilateral mastectomy does not improve survival outcomes for breast cancer patients. However, a study published in JAMA Oncology reveals a puzzling finding: Those who develop a second cancer in the other breast have a higher risk of death. As detailed in a…
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